Search Result

Results for "

anti-angiogenic activities

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Acyltransferase (1) ADC Cytotoxin (3) Akt (3) AMPK (1) Amyloid-β (2) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (3) AP-1 (1) Apoptosis (29) Autophagy (11) Bacterial (7) Bcl-2 Family (2) c-Kit (9) c-Met/HGFR (4) Casein Kinase (1) Caspase (2) Cholinesterase (ChE) (3) CMV (1) Complement System (1) COX (2) Dopamine Receptor (3) EGFR (2) Endogenous Metabolite (3) Enterovirus (1) Epigenetic Reader Domain (2) ERK (2) FAK (2) Ferroptosis (3) FGFR (7) FLT3 (3) GLUT (1) HCV (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (2) HIV (2) HSP (3) HSV (1) Influenza Virus (4) Integrin (3) Interleukin Related (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (2) MAP3K (1) MDM-2/p53 (1) MetAP (1) Microtubule/Tubulin (3) Mitophagy (2) MMP (2) Molecular Glues (1) mTOR (2) NF-κB (4) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Parasite (2) PARP (1) PDGFR (8) Phosphatase (2) PI3K (2) PPAR (1) Proteasome (1) PTEN (2) Raf (5) Reactive Oxygen Species (3) RET (3) SRPK (2) STAT (1) TAM Receptor (2) Tie (4) TNF Receptor (2) VEGFR (16)
By Research Areas:	Cancer (71) Cardiovascular Disease (16) Endocrinology (2) Infection (15) Inflammation/Immunology (19) Metabolic Disease (8) Neurological Disease (10)

By Targets:

5-HT Receptor (3)

Acyltransferase (1)

ADC Cytotoxin (3)

Akt (3)

AMPK (1)

Amyloid-β (2)

Angiotensin Receptor (4)

Angiotensin-converting Enzyme (ACE) (3)

Antibiotic (3)

AP-1 (1)

Apoptosis (29)

Autophagy (11)

Bacterial (7)

Bcl-2 Family (2)

c-Kit (9)

c-Met/HGFR (4)

Casein Kinase (1)

Caspase (2)

Cholinesterase (ChE) (3)

CMV (1)

Complement System (1)

COX (2)

Dopamine Receptor (3)

EGFR (2)

Endogenous Metabolite (3)

Enterovirus (1)

Epigenetic Reader Domain (2)

ERK (2)

FAK (2)

Ferroptosis (3)

FGFR (7)

FLT3 (3)

GLUT (1)

HCV (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Acetyltransferase (2)

HIV (2)

HSP (3)

HSV (1)

Influenza Virus (4)

Integrin (3)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (2)

MAP3K (1)

MDM-2/p53 (1)

MetAP (1)

Microtubule/Tubulin (3)

Mitophagy (2)

MMP (2)

Molecular Glues (1)

mTOR (2)

NF-κB (4)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (1)

Parasite (2)

PARP (1)

PDGFR (8)

Phosphatase (2)

PI3K (2)

PPAR (1)

Proteasome (1)

PTEN (2)

Raf (5)

Reactive Oxygen Species (3)

RET (3)

SRPK (2)

STAT (1)

TAM Receptor (2)

Tie (4)

TNF Receptor (2)

VEGFR (16)

By Research Areas:

Cancer (71)

Cardiovascular Disease (16)

Endocrinology (2)

Infection (15)

Inflammation/Immunology (19)

Metabolic Disease (8)

Neurological Disease (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147056

PKRA83 PKRA7	Others	Inflammation/Immunology Cancer
PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC₅₀ values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. PKRA83 can penetrate the blood-brain barrier .

HY-136901

Fusarochromanone FC-101	Reactive Oxygen Species	Cardiovascular Disease Cancer
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-160587

Antiangiogenic agent 5	SRPK	Cardiovascular Disease
Antiangiogenic agent 5 (compound 17) has anti-angiogenic activity. Antiangiogenic agent 5 show inhibition to SRPK1, with IC₅₀ of 1.3 nM .

HY-147969

Antiangiogenic agent 2	Nucleoside Antimetabolite/Analog	Cancer
Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC₅₀ of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .

HY-142085

Antiproliferative agent-20	Others	Cancer
Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities .

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N0793

Protopine Corydinine	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-117737A

RRD-251	Raf Apoptosis	Cancer
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities .

HY-N0205

Pulchinenoside C Anemoside B4	Others	Cancer
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

HY-18185

JNJ 17029259	VEGFR	Cancer
JNJ 17029259 is an orally active and selective VEGF-R2 kinase inhibitor. JNJ 17029259 inhibits VEGF-mediated signal transduction. JNJ 17029259 has anti-angiogenic activity .

HY-125741

GW768505A free base	Tie VEGFR	Cancer
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC₅₀ of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity 。

HY-N6258

Kahweol	AMPK Apoptosis	Metabolic Disease
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-115436

LYG-202	Apoptosis	Cancer
LYG-202, a flavonoid, has potent anti-angiogenic and antitumor activity. LYG-202 inhibits VEGF-stimulated HUVEC migration and tube formation. LYG-202 induces cancer cell apoptosis .

HY-129325

Cytochalasin H	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase	Infection Cancer
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

HY-100898

OGT 2115 2 Publications Verification	Others	Cancer
OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC₅₀ of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC₅₀ of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity .

HY-163402

EGFR-IN-108 chloride	EGFR Apoptosis	Cancer
EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC₅₀ value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects .

HY-156019

FGFR1 inhibitor-10	FGFR	Cancer
FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC₅₀: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect .

HY-N1067

Xanthohumol 5+ Cited Publications	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-124953

7,3',4'-Trihydroxyisoflavone	MAP3K Apoptosis	Cancer
7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities .

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Integrin Endogenous Metabolite	Cancer
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Cholinesterase (ChE) Enterovirus Opioid Receptor	Neurological Disease
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 µM. Corydaline is a μ-opioid receptor (K_i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Bacterial HIV Apoptosis	Infection Cancer
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-13737

R1530 1 Publications Verification	VEGFR FGFR Apoptosis	Cancer
R1530 is a highly potent, orally active, dual-acting mitosis/angiogenesis inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with K_d values of <500 nM. R1530 inhibits VGFR2 and FGFR1 with IC₅₀ of 10 nM and 28 nM, respectively. R1530 triggers apoptosis (mitotic catastrophe) or senescence .

HY-10220

SF1126	PI3K Apoptosis	Cancer
SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor, has antitumor and anti-angiogenic activity. SF1126 is an RGDS-conjugated LY294002 proagent, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. SF1126 induces cell apoptosis .

HY-107818

4-Hydroxychalcone	NF-κB	Cardiovascular Disease Inflammation/Immunology
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-N2533

Cyanidin 3-sambubioside chloride Cyanidin-3-O-sambubioside chloride	Influenza Virus Angiotensin-converting Enzyme (ACE)	Infection Inflammation/Immunology Cancer
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC₅₀ of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-P99386

Vesencumab MNRP-1685A	Complement System	Cancer
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer .

HY-161284

MMP-9/10-IN-1	MMP	Cancer
MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC₅₀s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) .

HY-B0965A

Thioridazine
Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-B0965

Thioridazine hydrochloride 3 Publications Verification	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Infection Neurological Disease Cancer
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-N6924

Zingibroside R1	HIV	Infection Metabolic Disease
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity . Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N0615

Notoginsenoside R1 1 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

HY-N0234

Bavachinin 2 Publications Verification 7-O-Methylbavachin; Bavachinin A	Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC₅₀ value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity. .

HY-108933

JK-P3	VEGFR FGFR	Cancer
JK-P3 is a potent and pan VEGFR2 inhibitor, with IC₅₀s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity .

HY-B0965AS

Thioridazine-d3 hydrochloride	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Neurological Disease
Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-101849

Fasentin 4 Publications Verification	GLUT TNF Receptor Apoptosis	Cardiovascular Disease Cancer
Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC₅₀=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .

HY-400684

Tubulysin A intermediate-1	Others	Cancer
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995). Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC .

HY-N4226

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid	AP-1	Inflammation/Immunology Cancer
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-B0965R

Thioridazine hydrochloride (Standard)	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Infection Neurological Disease Cancer
Thioridazine (hydrochloride) (Standard) is the analytical standard of Thioridazine (hydrochloride). This product is intended for research and analytical applications. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-W016412

Coenzyme Q0 2 Publications Verification CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Neurological Disease Inflammation/Immunology Cancer
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-136065

bpV(phen)	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-122818

bpV(phen) trihydrate 2 Publications Verification	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-N9396

Nasunin

Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside
NF-κB Metabolic Disease Inflammation/Immunology

Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity .
HY-N4094

Morellic acid

Others Inflammation/Immunology

Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .
HY-121382

Gypsogenin

Others Cardiovascular Disease

Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460 .

Nasunin Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside	NF-κB	Metabolic Disease Inflammation/Immunology
Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity .

Morellic acid	Others	Inflammation/Immunology
Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .

Gypsogenin	Others	Cardiovascular Disease
Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460 .

HY-12289

Defactinib 25+ Cited Publications VS-6063; PF-04554878	FAK	Cancer
Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

HY-133571

Aminohexylgeldanamycin AHGDM	HSP ADC Cytotoxin	Cancer
Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities .

HY-133571A

Aminohexylgeldanamycin hydrochloride AHGDM hydrochloride	HSP ADC Cytotoxin	Cancer
Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities .

HY-17601

Alofanib 3 Publications Verification RPT835	FGFR Apoptosis	Cardiovascular Disease Cancer
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity .

HY-12289S

Defactinib-d6 VS-6063-d₆; PF-04554878-d₆	FAK Isotope-Labeled Compounds	Cancer
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .

Cat. No.	Product Name	Target	Research Area

HY-P2284

AD 01	Peptides	Cancer
AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner .

HY-P1415A

Norleual TFA 1 Publications Verification	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-P1798

Platelet Factor 4 (58-70), human	Peptides	Cardiovascular Disease
Platelet Factor 4 (58-70), human, a peptide based on the amino acid sequence corresponding to residues 58-70 of platelet factor-4 (PF-4), contains the major heparin-binding domain, which is not sufficient for full antiangiogenic activity .

HY-12403A

Talfirastide acetate Maximum Cited Publications 9 Publications Verification TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-P1415

Norleual	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-12403

Talfirastide Maximum Cited Publications 9 Publications Verification TXA127; Angiotensin (1-7); Ang-(1-7)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0793

Protopine Corydinine	Alkaloids Structural Classification Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Cholinesterase (ChE)
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N0205

Pulchinenoside C Anemoside B4	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

HY-N6258

Kahweol	other families Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Diterpenoids Plants Disease Research Fields Coffea arabica L.	AMPK Apoptosis
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-136901

Fusarochromanone FC-101	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Reactive Oxygen Species
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Rosaceae Pseudocydonia sinensis (Thouin) C. K. Schneid. Plants	Cholinesterase (ChE)
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-129325

Cytochalasin H	Structural Classification Antibiotics Gramineae Source classification Plants Paspalum scrobiculatum L.	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

HY-N1067

Xanthohumol 5+ Cited Publications	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Integrin Endogenous Metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 µM. Corydaline is a μ-opioid receptor (K_i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Marine natural products Antibacterial Disease Research Other Antibiotics Infection Animals Antibiotics Antiviral Sponge Anticancer Disease Research Fields	Bacterial HIV Apoptosis
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-107818

4-Hydroxychalcone	Cardiovascular Disease Flavonoids Chalcones Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	NF-κB
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-N2533

Cyanidin 3-sambubioside chloride Cyanidin-3-O-sambubioside chloride	Infection Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Influenza Virus Angiotensin-converting Enzyme (ACE)
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC₅₀ of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-N6924

Zingibroside R1	Infection Classification of Application Fields Source classification Panax japonicas C. A. Mey. Metabolic Disease Plants Disease Research Fields Panax notoginseng Saccharides Araliaceae	HIV
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity . Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N0615

Notoginsenoside R1 1 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Panax notoginseng Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

HY-N0234

Bavachinin 2 Publications Verification 7-O-Methylbavachin; Bavachinin A	Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Psoralea corylifolia L. Plants Inflammation/Immunology Disease Research Fields	Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC₅₀ value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity. .

HY-N4226

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid	other families Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	AP-1
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-N9396

Nasunin Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside	Anthocyans Flavonoids Classification of Application Fields Solanum melongena L. Source classification Phenols Polyphenols Plants Solanaceae Disease Research Fields Inflammation/Immunology	NF-κB
Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity .

HY-N4094

Morellic acid	Natural Products Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Inflammation/Immunology	Others
Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .

HY-121382

Gypsogenin	Cardiovascular Disease Triterpenes Gypsophila perfoliata Linn . Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Caryophyllaceae	Others
Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460 .

HY-N5074

Terrestrosin D	Tribulus terrester Linn. Classification of Application Fields Zygophyllaceae Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis
Terrestrosin D, a steroidal saponin from Tribulus terrestris L., induces cell cycle arrest and cancer cells apoptosis. Terrestrosin D has antiangiogenic activities .

HY-N2732

6-Prenylapigenin 6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin	Structural Classification Flavonoids Flavones Source classification Maclura pomifera (Raf.) Schneid. Plants Moraceae	Others
6-Prenylapigenin is a biologically active flavonoid with anti-tumor activity and antiangiogenic properties. 6-Prenylapigenin exerts cytotoxicity against cancer cells, such as leukemia and solid cancer cells .

HY-N8178

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone	Cardiovascular Disease other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields	Others
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells .

HY-N0003

Honokiol 40+ Cited Publications NSC 293100	Structural Classification Magnolia officinalis. Rehd. et Wils. Classification of Application Fields Source classification Magnoliaceae Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Akt Autophagy HCV ERK
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier .

HY-N8342

Rhamnazin	Structural Classification Combretaceae Source classification Phenols Polyphenols Plants Combretum erythrophyllum Sond.	VEGFR
Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC₅₀ of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy . Rhamnazin shows antioxidant and anti-inflammatory properties .

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	mTOR
10-Hydroxy-2-decenoic acid (10-HDA) is the major lipid component of royal jelly produced by honeybees. 10-Hydroxy-2-decenoic acid has several health-beneficial effects in mammals, such as antitumor activity, anti-inflammatory activity, and antiangiogenic activity. 10-Hydroxy-2-decenoic acid also extends the lifespan of C. elegans .

HY-N2329

Piperlongumine 5 Publications Verification Piplartine	Infection Cardiovascular Disease Piper longum Linn. Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Piperaceae Plants Disease Research Fields	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-N2132

Flavokawain B 1 Publications Verification Flavokavain B	Flavonoids Chalcones Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

HY-D0803

Thymoquinone 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Nigella sativa L. Ranunculaceae Benzene Quinones Plants Inflammation/Immunology Disease Research Fields	Apoptosis VEGFR PI3K Akt
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-N0005

Curcumin Maximum Cited Publications 62 Publications Verification Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Food Research Microorganisms Sunscreen Phenols Polyphenols Pigments Cosmetic Research Curcuma longa Disease Research Fields Cancer Zingiberaceae	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-12403A

Talfirastide acetate 5+ Cited Publications TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-12403

Talfirastide 5+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

Cat. No.	Product Name	Chemical Structure

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-12289S

Defactinib-d6

Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .

HY-10330S

Toceranib-d8
Toceranib-d₈ is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks